Side effects are weird in that some of us will experience a specific side effect and many others do not.
I have a MTF friend who cannot tolerate any Estrogens because she says that they sap all her energy out of her. She lives a life where physical work is a daily experience and she likes to work out in the gym with her friends.
For myself, even though I am active, I do not need the extreme physical strength that you get from Testosterone. I am just fine with Estradiol.