I was placed on testosterone for a few years starting at age 16. I became irritable, depressed, prone to anger, and lost my ability to handle complex mathematics in my head. I was unable to focus on complex tasks.
I was placed on an antiandrogen, spironolactone, at age 62. After several weeks I began to experience periods of great calm, in which I could readily focus on complex tasks. Some of my old mathematics skill came back. With estradiol, I felt more energetic, more connected to myself, and that calm state became my new normal. I also gained easier access to emotional states.