According to the National Transgender Discrimination Survey, respondents experienced unemployment at double the rate of the general population, and 26% lost a job because of being transgender. 20% of respondents reported that they were evicted or denied housing simply for being transgender.
The National Transgender Discrimination Survey (NTDS) was conducted by the National Gay and Lesbian Task Force and the National Center for Transgender Equality from 2008 to 2009. This survey collected responses from over 6,450 participants across all states and the District of Columbia, plus Puerto Rico, Guam, and the United States Virgin Islands.
Perhaps more recent data is now available.