Quote from: Annaliese on April 20, 2025, 10:50:01 AMI've been researching options for additional testosterone suppression and came across Depo-Provera (medroxyprogesterone acetate).
I understand it's sometimes used off-label in transfeminine hormone therapy.
I'd love to ask a few questions about it to see if it might be a good fit for me."[/i]
I have been doing some research on anti androgens. I'm still not sure what is good for me, of course it is what is recommended by my provider, but I would like to have an input. I was going to make a post on this. But as I saw this I couldn't find anything on Depo Provera. I was wondering what many of you think.
It may not be available in the U.S., but I don't know that for certain.
I tried Spiro and Finasteride, but they were ineffective and interfered with my other hormones. They work by affecting the 5a reductase enzyme, which affects testosterone, estrogen, progesterone, and other hormones. Instead, they switched me to Eligard (leuprolide), which is an injection I get once every 90 days. It blocks testosterone production at the source. I also take Casodex (bicalutamide) tablets once per day. That does not interfere with any hormones but blocks androgen receptors, so any testosterone in the system will have no effect.
The body needs testosterone, not just for sexual function, but to be converted into other things the body needs. I think cholesterol is one of those. When you block testosterone, the body will convert a small amount of estrogen to testosterone, then to whatever it needs it for. By blocking the androgen receptors instead of attacking the hormone levels directly, the testosterone has no effect and can be converted to something else as needed.
I have found that it is a much better protocol and has been used for a long time as a form of chemical castration. Its primary use to to treat various cancers that target testosterone, so it has been proven effective.
The biggest obstacle is cost. Many providers will not prescribe it because it is expensive, and they know that a patient is less likely to follow a protocol if they can't afford it. My prescriptions are provided through the Veterans Administration, so they cost me nothing. If your insurance covers it, I would highly recommend it.