I'm happy to help. When the doctor begins to prescribe, she may only prescribe an anti androgen, such as spironolactone, which has some feminizing effects best described elsewhere. After a few weeks or months, as long as the blood work remains stable, estrogen may be introduced in small doses, gradually working up to what will be your daily dosage. There is no real research that has been done that all doctors will use to guide them, so it's a combination of their experience, what they have read, and sound medical judgement that guides them. The doctor wishes to establish the optimum dosage for you along with a margin of safety. The estrogen medications that we use are really marketed for biological women, the use in GID clients is not supported by the drug manufacturers.
You'll be asked to sign an "informed consent" form prior to beginning treatment. This is to protect the doctor, should you change your mind in the future, and then turn around and sue because you've been on HRT for a period of time, and can no longer father children. The doctor may also ask you to consider options for future reproduction, such as banking sperm. If your wife asks what she can expect as far as any changes in your personality or behavior, there really is no answer since not everyone responds the same way. Some become more emotional, some don't. Personally, I've become less emotional, better balanced, more stable. More "solid." Some people respond entirely differently. You won't know until you try it, but if it does become a problem, and it most likely won't, just discuss it with your prescribing doctor.
