Personally, I'm moving to Denver in 2 months. Colorado has the same laws about transgender equality/rights that California has... honestly, probably the most liberal in the country. Denver is a nice-sized metropolis with not only numerous trans resources, but tons of things to do, and at least 5 good universities. If you're like me and support medical marijuana, the laws in California regarding that subject are only slightly more liberal than those in Colorado, though CO is catching up quite well... not to mention that Denver is the only place in the U.S. where the law equates marijuana use/possession to that of alcohol.
Yes, it's about a 15-hour drive from Los Angeles, or a 20-hour drive from San Francisco, but as far as your family goes, just remind them that you can get anywhere in the country within 1-4 hours by plane, and flight costs are significantly less than they were only a few years ago.
Oh, and the temperatures in Colorado can be extreme, but Denver's about the best as far as cities go. Summer temps can get as high as 90, but from March to October or November, it stays around the 60-75 degree range more often than not.
SD