It seems to be common practice for endocrinologists to reduce the estrogen dosage by 50% after removal of the testes (as part of SRS or orchiectomy) and cessation of anti-androgens.

The intent does not seem to be a reduction in effectiveness of hormone therapy, but maintenance at an equivalent level.

Can anybody cite a scientific rationale why estrogen would be more effective with testes and anti-androgens out of the picture?

hey you! glad you had a good experience.  Its funny you should ask this ? because I was wondering too.  Wouldnt it make sense to keep blood E levels at roughly F puberty levels for at least several years. 

Quote from: Audrey on April 30, 2009, 03:27:46 AM
hey you! glad you had a good experience.  Its funny you should ask this ? because I was wondering too.  Wouldnt it make sense to keep blood E levels at roughly F puberty levels for at least several years.

This is the approach that my endoc is using. She is keeping me on the same dose of EV for a while post grs. We are adjusting my levels as needed based on blood work.

OH Oh I know this one.  Pre-op you need more E to overcome the T production.  Post Op the E levels are reduced so that the E concntrations does not jump higher (this since T is dropped way down).  Ie you need less E after to maintain the same overall bloodlevels, post op then prior..

So no worries there is a medical reason to reduce E after surgery.

Beni

I'm on the same E dose pre-op vs post-op. *shrugs*


--natalie