From further back, it looks masculine, but the guard makes it look a bit feminine up close. However there is so much androgyny and men in music embracing flowers and such these days, it doesn't matter one bit. It looks good as it is, male or female.
You can get acrylic at hardware stores like Lowes and Home Depot for cheap. You can cut it with wood tools, Dremel (engraving, and cutting), jigsaw, scroll saw, or a table saw even. It's quite soft. Just try not to melt it as you cut, which tends to happen easy. Lexan is easier to work with and more durable, and won't yellow as easy over time, but is sticky as it melts, I had a chuck go flying across the garage when i cut it with my table saw (only once, and part of it was my fault. I cut lots without problems).
As for drilling it, they make bits for plastic but all they are is normal bits with a flatter tip. I have drilled it with Dremel grinding stones, normal drill bits with a piece of wood clamped under the acrylic so it doesn't chip as it exits (go SLOOOOW) and sometimes I went lazy and just used a soldering iron and pushed it through, this is the best hole and safest way for the acrylic but not the healthiest method for you if you breathe the smoke. You have to clean off the flashing when you are done though or you get a raised edge around the hole.