A few yrs ago my mother was having to take estroen daily. Then she stopped with several refills left. You can imagine what I wanted to do. And I did. Crazy I know, but I am sure I was not even close to the correct dosage needed. However I do remember feeling some light tingles/tenderness though. It did make me mentally feel better during that time. Of course after the refils run out, I could get no more. So, I know having yourself monitored is the best way, but has there ever been anyone getting them otherwise? I wouldnt do that, because of the risk, just curious. Oh and thanks so much for all of u making me feel welcome here.....Christy E