If I could take a magic pill that caused my brain to match my body... If I would become a comfortable, well-adjusted female with a great female body...
My answer is yes, I would do it.
Here's why.
As a transguy, my mind doesn't match my body. I do a lot of thinking about my situation, and I still don't know if it's my mind that is wrong or my body that is wrong. One of them doesn't match the other, and unfortunately for my body I think with my mind, and my mind has decided that it is right and my body is wrong. But if I could take a pill that would match my mind to my body, that would fix everything.
Being trans isn't a part of my personality. It doesn't matter if I'm a cisgirl, cisguy, transguy, or transgirl. However I am, I am still me. The only difference is that as a cisgirl or cisguy I would be satisfied with my body and my mind.
You are all forgetting that even though you don't want to be stuck in the body you were born with, if you were no longer trans you would be happy. Think about it. I don't want to be a girl, but if I took that pill and my mind was changed, I wouldn't be an unhappy girl. Memories of being an unhappy, dysphoric transguy would just be that: memories. Just like memories of being depressed after breaking up with someone I loved. I don't feel that way anymore! I'm happy without him.
I know I'm going to get a lot of ->-bleeped-<- for this, but this is just what makes sense to me. Being trans is a source of so much pain, so much discrimination, so much conflict. Transition is treatment for gender dysphoria. Having your mind and body suddenly magically match up would be a cure.