what symptoms?
It could be a lot of things. Best to get a doctor to check it out.
I hope she is getting regular blood tests. They will tell you a lot. Would rule out kidney issues etc..
Hormones can leave you fatigued, make you urinate a lot (especially as estrogen tends to shrink your bladder and spiro is a diuretic), hormones can darken your aureol, cause headaches, sore breasts and nausea. All are possible side effects of hormone therapy.