The shape of your eyes, unless you're not past puberty, 99,99% chance the answer is no. Even if you're not, maybe HRT wouldn't even have an effect actually.
But the "feminine shape" is not all that much caused by the eyes. I think it's more about the way the face surrounds the eyes : females have "less eyebrows, more cheeks", which makes the eyes larger. This, however, CAN be affected by HRT. If you're not past puberty, you've a great chance. If you're just past puberty, you still have a chance.
I've also read that HRT can actually have an effect on the bones, including the face, with a low success rate, no matter the age. The younger, the more likely. Nothing very drastic, though, but it's not something I'd decline. Another reason for starting HRT as swiftly as possible - Some stories report male puberty effects being partly cured by fast HRT.
But if this truly is a problem for you (and I think even after HRT it will be for me too), FFS might be your best option. Just correcting the eyebrow bones could do miracles.
HRT=Hormone replacement therapy, usually with estrogen, anti-androgens and (not always) progesterone for MTFs
FFS=Face feminization surgery
PS : Drugs that change eye colour ? Excuse me ? Sure does sound like a manga story. Are you sure ?