the most important thing, when you set the injection is..to really take it as slow as you can, it is a very thick liquid and if you do it fast a bubble can built, nothing dangerous, but it can hurt a few days until it goes down. should that happen have a warm bath, that usually eases the pain and loosens it. If you set the needle right...and take it real slow..it does not hurt at all. The actual needle might be a little sting if at all. If you are really scared, also there is no need, you could opt for the gel or the patches, but I would recommend to take the injections at least for the first 3 years because it is a much higher dose and it will aid so much better your transition ...your voice breaking and your looks. In fact, when I change to the gel...I think 4 years into my transition I felt a bit of a setback in a few areas. The injections are the best option in my experience. good luck