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Started by Lord of the Dance, February 18, 2011, 06:43:21 AM
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QuoteHigh-dose androgen administration to female-to-male transsexuals showed many effects in vivo, and appeared to increase weight, increase visceral fat, increase hematocrit, decrease HDL cholesterol, increase endothelin-1, increase C-reactive protein, and increase tHcy. These assessments of cardiovascular risk factors showed convincingly a shift to a more negative risk profile which could be demonstrated to be androgen related, which raises concern for atherosclerotic and thrombotic events.Yet blood pressure, insulin sensitivity, fibrinolytic markers, arterial stiffness, and levels of vWF, fibrinogen, and interleukin-6 remained largely unchanged. Also, administration of androgens to 293 female-to-male transsexuals with a total exposure of 2,481 patient years (individual exposure varied from 1 to 20 years) was a safe procedure in a retrospective study [89]. There were no major complications. The actually observed cardiovascular mortality and morbidity was not higher than expected on the basis of Dutch health statistics.This includes an increasing number of female-to-male transsexuals in our population over the age of 50. The observation that cardiovascular risk factors shift to a male-like risk profile has prompted us to encourage female-to-male transsexuals to adopt a healthy lifestyle: avoidance of overweight, a healthy diet, enough exercise, and no smoking. Indeed, in some aging female-to-male transsexuals, we observe the development of the metabolic syndrome. It is our policy to follow up hormone-treated transsexuals throughout their lives to treat and make an inventory of long-term complications. Transsexuals, in their understandable desire to embark on life in the desired sex, tend to sever ties with the clinic that provided sex reassignment.Dosages of androgens suited for replacement in women are much lower than those needed for sex reassignment in female-to-male transsexuals. Traditionally, in transsexuals, the classical parenteral testosterone esters have been used, resulting in supraphysiological plasma testosterone levels in the first days after the injection. Recent studies with the long-acting parenteral testosterone undecanoate show a much more favorable pharmacokinetic profile [77,78]. Also, transdermal administration of testosterone gel is a major improvement in testosterone treatment. The suitability of testosterone preparations for treatment of female-to-male transsexuals is not different from those used for hypogonadal men [90,91].The implications of the aforementioned review for androgen administration to women are that it is reasonable to assume that the dosages given to women will be less detrimental to cardiovascular risks than those administered to transsexuals.
Quote from: Dominick_81 on February 18, 2011, 09:33:26 PMI thought the only thing after starting T was just getting blood test to check T levels? There's more blood test ya gotta get?
Quote from: Andrew Scott on February 18, 2011, 09:36:23 PMSometimes they check your liver and some other things as wellTo the OP I'm not sure but since I'll have to be getting the tests done I'm just kinda subscribing to the thread to find out. Ultimately it'll come down to what your doctor wants I've heard of some guys needing a ton of tests while other doctors don't order as many. Good luck with the bloodwork
Quote from: Andrew Scott on February 18, 2011, 09:51:30 PMThanks man! Your doctor should know what tests to look for but if not, they should be doing research to find it out. My doctor hadn't had a trans patient before me and said that the tests should be similar to the ones they do for bio guys who have to use testosterone shots to up their T because their body isn't making enough for whatever reason. Our results I'm assuming will be different at first but as we're on T for a long time the results should be similar I believe. Feel free to correct me if I'm wrong anyone
Quote from: Andrew ScottGood luck with the bloodwork