FWIW I'm on Reandron (Nebido for those of you in parts other than Aus) and yes it is a large injection and a slow push and it does sting from time to time but nothing too bad!! And I have done it myself and had mates do it too - though granted I and my friends have medical training, but it's the same as any other shot mate.
Changes in my opinion were stock standard - my arm hair is the slowest thing to come in yet! My GP started me on the shot every 6-8 weeks to get my T levels into the normal male range and now its the standard 10-12 weeks between shots. As for the monthly visitor, I started T in the Nov and have had one period in the Dec since.
But research it for yourself mate, this is just my experience. Watch my youtube vids if you're keen to see the changes and timeline etc.