Quote from: Zoë Natasha on June 08, 2011, 10:33:42 AM
1.- I don't understand the whole "caffeine and hormones" mechanism (and I have a distinct love of studying biology).
2.- Tried to break myself off the caffeine but I've found that the cognitive slowing from my severe depression is far too great and I bawl for hours when I have no caffeine.
3.- Going to ask my doc when I see her next week about adding antidepressants to the mix
4.- (as well as finding a different AA than spiro, which didn't work, and depo, which might be making me depressed).
Crit Rev Food Sci Nutr. 2011 Apr;51(4):363-73.
Coffee and its consumption: benefits and risks.
Butt MS, Sultan MT.
Source
National Institute of Food Science and Technology, University of Agriculture, Faisalabad, Pakistan.
drmsbutt@yahoo.comAbstract
Coffee is the leading worldwide beverage after water and its trade exceeds US $10 billion worldwide. Controversies regarding its benefits and risks still exist as reliable evidence is becoming available supporting its health promoting potential; however, some researchers have argued about the association of coffee consumption with cardiovascular complications and cancer insurgence. The health-promoting properties of coffee are often attributed to its rich phytochemistry, including caffeine, chlorogenic acid, caffeic acid, hydroxyhydroquinone (HHQ), etc. Many research investigations, epidemiological studies, and meta-analyses regarding coffee consumption revealed its inverse correlation with that of diabetes mellitus, various cancer lines, Parkinsonism, and Alzheimer's disease. Moreover, it ameliorates oxidative stress because of its ability to induce mRNA and protein expression, and mediates Nrf2-ARE pathway stimulation. Furthermore, caffeine and its metabolites help in proper cognitive functionality. Coffee lipid fraction containing cafestol and kahweol act as a safeguard against some malignant cells by modulating the detoxifying enzymes. On the other hand, their higher levels raise serum cholesterol, posing a possible threat to coronary health, for example, myocardial and cerebral infarction, insomnia, and cardiovascular complications. Caffeine also affects adenosine receptors and its withdrawal is accompanied with muscle fatigue and allied problems in those addicted to coffee. An array of evidence showed that pregnant women or those with postmenopausal problems should avoid excessive consumption of coffee because of its interference with oral contraceptives or postmenopausal hormones. This review article is an attempt to disseminate general information, health claims, and obviously the risk factors associated with coffee consumption to scientists, allied stakeholders, and certainly readers.
Parkinsonism Relat Disord. 2010 Jul;16(6):370-5. Epub 2010 Mar 20.
Polymorphisms of caffeine metabolism and estrogen receptor genes and risk of Parkinson's disease in men and women.
Palacios N, Weisskopf M, Simon K, Gao X, Schwarzschild M, Ascherio A.
Source
Dept. of Nutrition, Harvard School of Public Health 655 Huntington Ave., Boston, MA 02115, USA.
palacios@hsph.harvard.eduAbstract
Caffeine intake has been associated with a decreased risk of Parkinson's disease (PD) in men but the effect in women is less clear, and appears to be modified by use of post-menopausal estrogens. In a nested case-control study within the Nurses Health Study (NHS) and the Health Professionals Follow-up Study (HPFS), we examined associations between single nucleotide polymorphisms (SNPs) of caffeine metabolizing genes (CYP1A2 and NAT2) and estrogen receptors (ESR1 and ESR2), their interaction with caffeine intake and hormone replacement therapy (PMH) use (collected prospectively) and risk of PD. We matched 159 female cases to 724 controls and 139 male cases to 561 controls on birth year, source of DNA (blood or buccal smear), age and sex. The CYP1A2 rs762551 polymorphism (lower enzyme inducibility) was marginally associated with an increased risk of PD (RR, for increasing number of minor alleles=1.34; 95% CI 1.02, 1.78 in women, but not in men. None of the NAT2 (classified as slow vs. fast acetylator), ESR1 or ESR2 polymorphisms were significantly associated with an altered risk of PD. Marginally significant interactions were observed between caffeine intake and the ESR1 polymorphism rs3798577 (p=0.07) and ESR2 polymorphism rs1255998 (p=0.07). The observed increased risk of PD among female but not male carriers of the rs762551 polymorphism of CYP1A2 and the interactions of caffeine with ESR1 rs3798577 and ESR2 rs1255998 may provide clues to explain the relationship between gender, caffeine intake, estrogen status and risk of PD and need to be replicated.
1.- It only applies to excessive consumption 4 or mor cups a day.
2.- Stay with yur coffe
3.- If you do not have to take anti depresants, PLEASE do not take them. Morere often than not, it is a life-time deal. WE do not fully understand the long-term consequences of anti depressant use.
4.- You mean spiro at it highest does has failed to reduce your total T asnd free T?
Kate D
