I too have this issue. I have tried effexor. wellbutrin, paxil, prozac, celexa, and I think a couple others in there..the xanax helps, though I don't take it any longer..but what seemed to help me the most was buspirone.
I had never heard of it before. So i did a little research..
5-HT1A receptor agonists like buspirone[14] and flesinoxan[15] show efficacy in relieving anxiety[16] and depression,[17] and buspirone and tandospirone are currently approved for these indications in various parts of the world. Others such as gepirone,[18] flesinoxan,[15] flibanserin,[19] and PRX-00023[20] have also been investigated, though none have been fully developed and approved as of yet. Some of the atypical antipsychotics like aripiprazole[21] are also partial agonists at the 5-HT1A receptor and are sometimes used in low doses as augmentations to standard antidepressants like the selective serotonin reuptake inhibitors (SSRIs).
5-HT1A receptor activation induces the secretion of various hormones including cortisol, corticosterone, adrenocorticotropic hormone (ACTH), oxytocin, prolactin, growth hormone, and β-endorphin.[55][56][57][58] The receptor does not affect vasopressin or renin secretion, unlike the 5-HT2 receptors.[55][56] It has been suggested that oxytocin release may contribute to the prosocial, antiaggressive or serenic, and anxiolytic properties observed upon activation of the receptor.[25] β-Endorphin secretion likely contributes to antidepressant, anxiolytic, and analgesic effects.
Interesting part was how it may induce secretion of various hormones. Hence it makes me wonder in the case of being trans what exactly it did to make me feel better. It didn't cure my g.i.d by any means, but it did lessen the anxiety a considerable amount, just as hrt did.