This is an excellent subject. I may be what is called a maintenance level alcoholic, although I have enormous willpower and have quit for up to five years. I've been on several types of estrogenic applications for over ten years and don't use Spironolactone as the gonads have been gone almost as long. I have found out that my two cocktail per day self imposed limit has actually accentuated the effects of estrogen, this information is backed up by my lady doctor who specializes in HRT for both men and women. I have noticed that if I go beyond my two drink limit for upwards of a week that my blood pressure spikes and I start getting horrible leg cramps in the groin, the hamstrings as well as the calf muscles. Not fun on the toilet during a pee session either, so I set the self imposed maximin of no more than two cocktails within a 24 hour period and it works. I suppose it would be even better it I quit because each drink is a double shot which translates to 240 useless, fat promoting calories each. I just haven't arrived at that place yet!