Quote from: Zylphia on February 22, 2012, 12:54:45 AM
Well in all honesty I have read some studies and reports (although I am much to lazy to look them up) that say no method and no oestrogen is more affective than the next.
All across the spectrum as I have read in the reports I come across say that it is relatively even (although with room for debate as with anything).

I believe this theory and oral is probably the easiest and most sure fire way of taking oestrogen, As I think none has more feminizing effects than another.

I have said the same thing over and over like the school board trustees.

You're right, your serum hormone levels are what has the effect, how you get there shouddn't significantly matter.

Quote from: Asfsd4214 on February 22, 2012, 12:59:36 AM
You're right, your serum hormone levels are what has the effect, how you get there shouddn't significantly matter.

This is very true.. Also dividing your oral or sublingual dose also doesn't do much either..

Shots > Pills.

So. Much. Better.

More effective? I think not. Probably a better way to get it in your system though.

Quote from: Caith on April 17, 2011, 08:17:28 PM
Oral use (swallowing) of estradiol tablets doesn't provide good absorption of your dosage, because of your digestive system and first-pass through the liver.  This is the least effective method of delivery.
Sublingual (beneath the tongue) use of estradiol tablets provides approximately 80% delivery of your dosage.  For most people, it's a very effective method of delivery.
Intramuscular injections are generally more effective, providing almost 100% delivery of your dosage.  Many people don't care for the effort and trouble of weekly injections.  Some people have issues when their weekly dosage runs short a day or two before their next injection.

Sublingual delivery has been good for me, personally.  I'm similar to Janet Lynn in that I've had decent breast development, but no effects whatsoever in the areas of hips or bottom.

And if I may add, transdermal (patches) also avoid the filtering effect of the liver.  Their effectiveness is debated but if breast development is used as a barometer, I got to a small B on transdermal patches.  But breast development is such a small part of the overall effect hormones have on a person. 

Looking back, I think the biggest impact hormones had on me happened between my ears.  It's a slippery slope.  So when trying to achieve maximum hormonal effectiveness, consider all the aspects and the impact they may have.

I would love to have the opportunity to find out! but shots are illegal in the U.K 

I get really upset with you American girls because you can try shots!

Quote from: Naturally Blonde on February 22, 2012, 02:13:48 PM
I get really upset with you American girls because you can try shots!

I'll drink to that!

Quote from: Julie Marie on February 22, 2012, 02:42:50 PM
I'll drink to that!

Yes, but how do you think I feel?.... pretty pissed about it!

i read on the internet that the injections are better cause they dont really hurt ur liver as much as taking the pill does and i also heard that they make u see changed quicker than u would if u go on pills. you take them every 2 weeks

Quote from: Angelique1994 on February 26, 2012, 02:16:15 AM
i read on the internet that the injections are better cause they dont really hurt ur liver as much as taking the pill does and i also heard that they make u see changed quicker than u would if u go on pills. you take them every 2 weeks

Every week for me.

Quote from: Angelique1994 on February 26, 2012, 02:16:15 AM
i read on the internet that the injections are better cause they dont really hurt ur liver as much as taking the pill does and i also heard that they make u see changed quicker than u would if u go on pills. you take them every 2 weeks

Injection forms have a half life of 5-6 days... so by the 13th / 14th day most are getting pretty low on E. It's best to give yourself a shot every week. If a doctor prescribes you a certain dosage for every 2 weeks, I would say you should half your dosage and take it every week. I'll be doing this on my next shot. Besides... having astronomical estradiol levels is NOT fun...

Quote from: Angelique1994 on February 26, 2012, 02:16:15 AM
i read on the internet that the injections are better cause they dont really hurt ur liver as much as taking the pill does and i also heard that they make u see changed quicker than u would if u go on pills. you take them every 2 weeks

HOW? can I purchase them in the U.K as they are not legal here in the U.K? any reputable on line sources I can purchase them from? keeping in mind I have full medical support from my endo!

I'm getting fed up of being ignored in this forum and everybody from the USA rubbing it in how wonderful shots are knowing I can't get them over here in the U.K!

I go to a very big well known uhmm dr office place (watever sorry im stupid) for my hormones that specializes in it.  Every now and then my endo seems to change.
The first one told me the injections would provide faster results with less risks. 
The second endo "didn't want to say" (thats how she said it) that i should expect any better results by switching to intramuscular from sublingual.  She also told me the risks were the same.
About to be on my third endo so im interested in her view on this..

Just switched in injections so i guess i will see.  I hate needles but so many pills a day is too much for me.

I'm on Neofollin injections once per week. It's 5mg of estradioli valeras (synthetic estradiol identical to estrogen and the rest of the 1ml vial is filled with sunflower oil as a medium). The physical and psychological effects I experienced are way beyond what I've read in a textbook for doctors which discussed pills. However I have to add that I was on Androcur 50 for 5 weeks before Neofollin was added and never had any masculine features besides facial and body hair.

I first noticed breast development after 4 days. Nipple and breast sensitivity spiked up after 8 days. After 3 weeks my sexuality reactivated but it was completely different (female libido, yay :-) ). And my face changed so rapidly in one month and a half that I was no longer talked to as a man by  random people. After 8 weeks I visited my therapist and even though he's normally very professional I could notice a surprised stare. And one funny note: the regular weekly injections gave me a very regular mood cycle. At least the worst day isn't by far as bad as my older sister's PMS :-) .

And from what I've read on local Czech site the general experience is that Neofollin response is very strong when compared to Estrofem or Estrimax (pills). However Neofollin is rarely prescribed for a very good reason: high risk of serious side effects for patients who have history of smoking, drinking or drugs, had circulatory issues like phlebitis, epilepsy and like 50 more items on the list... Nearly perfect health record is required for this stuff to be prescribed.

A dose is  a dose. And we cannot talk about dosage levels here. That said, proper management will put your serum levels where they need to be, regardless of delivery.

there is always a lot of debate over these topics, but I think it all comes down to the individual experience. The key is being happy with whatever method you choose from what is available to you.

For me it would be pellets > patches > injections > pills

general take on pros/cons from my own standpoint (can you guess which one I'm using? ) disclaimer: I am not a doctor and not pretending to be one... take this worth a grain of salt

Pellets
+ steady dose release over 3-6 months
+ no peaks/valleys
+ no daily routine
+ cheap on low dose
+ more effective, quicker feminization (as a product of steady release, no valleys)
+ easy on liver
+ very stable mental state (as a product of steady release)
+ very easy on the body (closest possible thing to actual ovaries)
+ no side effects
+ easy to forget about being on HRT
- must be surgically implanted in office by a doctor
- more expensive when starting out (but faster feminization)
- cannot "cancel" a dose
- must keep bandage dry for first 3 days after treatment

Patches
+ easy on liver
+ can be applied at home
+ fast feminization
- can fall off
- can cause rash/allergy to adhesive
- peaks & valleys

Injections
+ easy on liver
+ can be applied at home
+ fast feminization
- involves needles on a weekly basis
- severe peaks & valleys
- possible mental effects due to hormone surges
- testosterone can rebound during valley (impedes feminization)

Orals
+ cheap
+ easy to administer
- slowest feminization
- bad for liver
- bad for mental state
- daily peaks & valleys
- daily routine

Quote from: Jennygirl on June 25, 2014, 07:21:24 AM

Orals
+ cheap
+ easy to administer
- slowest feminization
- bad for liver
- bad for mental state
- daily peaks & valleys
- daily routine

well.. this is a bit discouraging my endo seems adamant about keeping me on pills, telling me that injections or other methods are only necessary if I plateau, he doesnt even seem to use patches >_< would I be wrong if I went to my endo and said "I want faster methods please"? 

Quote from: LittleEmily24 on June 25, 2014, 10:54:41 AM
well.. this is a bit discouraging my endo seems adamant about keeping me on pills, telling me that injections or other methods are only necessary if I plateau, he doesnt even seem to use patches >_< would I be wrong if I went to my endo and said "I want faster methods please"?

Absolutely not!  I went right up to my endo and said, "I want patches as my delivery method because I feel it's safer for me."  And he prescribed me a popular name brand patch that sticks on you and doesn't want to let go!  It costs more, that's for sure, but it seems to be really harmonious with me in particular, if that makes any sense.  So just go to your endo and be adamant about it.

yes I agree 100%. You should be adamant and confident about it.

You could even say that the orals are not working out for you. Then you could gauge whether it's a good idea to bring up other methods (you might not want to offend them if they are the only one in your area).

If your endo makes you feel uneasy about asking about other methods though, it sounds like it's not an endo who truly cares and just wants to take your money and send you out of the door. In that case I would start looking for a better endocrinologist.

Quote from: Jennygirl on June 25, 2014, 07:21:24 AM
there is always a lot of debate over these topics, but I think it all comes down to the individual experience. The key is being happy with whatever method you choose from what is available to you.

For me it would be pellets > patches > injections > pills

general take on pros/cons from my own standpoint (can you guess which one I'm using? ) disclaimer: I am not a doctor and not pretending to be one... take this worth a grain of salt

Pellets
+ steady dose release over 3-6 months
+ no peaks/valleys
+ no daily routine
+ cheap on low dose
+ more effective, quicker feminization (as a product of steady release, no valleys)
+ easy on liver
+ very stable mental state (as a product of steady release)
+ very easy on the body (closest possible thing to actual ovaries)
+ no side effects
+ easy to forget about being on HRT
- must be surgically implanted in office by a doctor
- more expensive when starting out (but faster feminization)
- cannot "cancel" a dose
- must keep bandage dry for first 3 days after treatment

Patches
+ easy on liver
+ can be applied at home
+ fast feminization
- can fall off
- can cause rash/allergy to adhesive
- peaks & valleys

Injections
+ easy on liver
+ can be applied at home
+ fast feminization
- involves needles on a weekly basis
- severe peaks & valleys
- possible mental effects due to hormone surges
- testosterone can rebound during valley (impedes feminization)

Orals
+ cheap
+ easy to administer
- slowest feminization
- bad for liver
- bad for mental state
- daily peaks & valleys
- daily routine

I do patches I think there good , but sometimes you need to baby them because perspiration will make them fall off. You just need to dry the skin underneath and reapply .