Quote from: Seyranna on April 18, 2012, 06:52:13 AM
BTW injectable Estrogen is dangerous and highly overrated it's no longer prescribed here in Canada too.

Well, I think patches and gels are overrated and did absolutely nothing for me. Pills haven't been that impressive either (I've been on HRT for 12 years). But I've not tried shots so I can't make a judgement on them but I would like to try them to find out for myself how effective they are. In the U.K the are not licensed so I'm not sure how to go about getting them?

As for Injectable HRT being dangerous, Spiro is considered to be dangerous over here in the U.K! and different countries have different rules for various medications.

No delivery method is really any better than any other, it's the serum level that's important..

Quote from: kelly_aus on April 19, 2012, 06:44:40 AM
No delivery method is really any better than any other, it's the serum level that's important..

Serum level? please clarify?

Quote from: kelly_aus on April 19, 2012, 06:44:40 AM
No delivery method is really any better than any other, it's the serum level that's important..

Not really. There aren't any actual scientific studies on trans women to prove it but from my own exp with different delivery methods (orals,patches, and injectables) and from the testimonies of countless other trans women I've come to the conclusion that injectbales or estrogen implants (pellets) are far superior to orals, gel, and even transdermals.

The serum level of estrogen; how much you have in your body and how stable the amount is.

Quote from: A on April 19, 2012, 04:45:15 PM
The serum level of estrogen; how much you have in your body and how stable the amount is.

You can have high oestrogen levels like I always seem to have and not get the development you need. It doesn't work on that theory that the higher the levels are the better the HRT works. It's more related to your genetics.

Quote from: Naturally Blonde on April 19, 2012, 05:20:06 PM
You can have high oestrogen levels like I always seem to have and not get the development you need. It doesn't work on that theory that the higher the levels are the better the HRT works. It's more related to your genetics.

That's not an issue with the delivery method though, which is what I was talking about.. I was merely stating that no delivery method was in fact superior to any other..

Quote from: kelly_aus on April 19, 2012, 05:28:43 PM
That's not an issue with the delivery method though, which is what I was talking about.. I was merely stating that no delivery method was in fact superior to any other..

The only difference I would see is first pass (going through the liver first) can be harmful. I know with the med they are trying with me now (estriol), trans-dermal cremes are, for the same MG taken, 10X+ more effective than if orally taken. I would think injections wouldn't be ideal either given they would spike the levels and than taper off till the next shot. Maybe I'm thinking wrong but transdermal should be able to maintain more even levels if you can get the levels in a good place with them..

It's as you say, or so I believe. However, transdermal being the smoothest and releasing the slowest, even though levels are more stable, it still doesn't deliver as high a maximum dose in the blood as injections or even pills do, which is why people usually report faster results with injections and, to a lower extent, pills. But in theory, both of these should not be more effective, maybe even less, than transdermal in the long run, I think. Now, as for transdermal being actually better, I don't know. What's sure is that it's by far the safest, unless you get rashes because of the patch's adhesive, but that's another story.