Aniya,
My greatest concerns about HRT are allergic reaction, sudden or drastic changes in mental / emotional states, possibility of stroke / heart problems, and other documented negative effects. I could care less if my equipment works or not because I have no desire to procreate. I posted about my concerns here at Susan's (mainly about allergic reactions) and got some productive, helpful answers.
I'm just taking this slowly, one day at a time, and waiting to see where therapy leads me once it starts. I hope my post has been helpful for you.