Yes, I stopped after two years on a full dose. Things didn't feel like they were working out so I pulled the plug. Hormones will have some effect on your body regardless of the length of time you are on them or strength. Some changes will reverse fairly quickly, but others may take longer and others generally never do - breast development and growth, for example. You might want to bank sperm if you plan for children - my experience was that HRT the first time around took that option away from me, not sure of the biology involved but the wrigglers were not in high numbers or very fertile afterwards. If you do stop, make sure it is with proper medical supervision.