I'm not on HRT but I have been on anti depressants for just over a year. Even though I knew they would be OK I still took some persuading that I needed them. It turned out I absolutely did need them, they helped me through some of the lowest points of my life.
My view of them is that they are not the solution for depression they are there to stabilize your mood to give you the chance to fix the actual cause of it and you only need them for as long as it takes.
In my case I had improved enough to consider coming off them until something happened to tip me back down the rabbit hole somewhat. However out of that incident I discovered that I am probably trans and my mood improved massively.
I am optimistic that I will stop taking them in about 6 months when they have done their job. I do know people who have been on them for 10 years because they still need them but are completely fine with that. Its what is right for you.
In terms of side drug effects I have no fog with mine, in fact the fog I did have has cleared up so clearly this one is right for me. I did however have one of the major side effects listed.
I started on half dose but at my lowest that got increased to the max dose. After that I found myself being very very agitated to the point of pacing up and down a lot.
Once I went back to half dose everything returned to normal so half dose is about right for me. What got me through this I think is the combination of half dose and a good counselor.
I suspect that HRT won't interact very much but only a doctor can tell you for sure.
I hope this helps anyone considering anti-depressants.they are nothing to be afraid of and can be enormously helpful with good guidance.
