I don't have a prostate, but I use my ass for that all the time. I don't have a lot of bottom dysphoria, either, so I'm not just avoiding "female" bits. In my experience, anal sex is an acquired taste just like beer or coffee. Kinda repellent to begin with, but it's got it's subtleties, and there's nothing else like it.
I use enemas and general cleanliness to insure that it's not a traumatically dagnasty experience, though. No santorum on my sheets.
Whether JenJen's comment was serious or facetious, she has a point. Penetration is nice and doable no matter what your body situation is.