Can MtF with Kleinfelters skip Anti-Androgens when starting HRT?

[Rosa]

Anyone have experience or info with this? 

[Tyler]

I don't believe so. They still would have testosterone in there system regardless of genetic disorder.

[xxUltraModLadyxx]

i have all the symptoms of klinefelter's, except it's mosaic. if your bloodwork has shown that testosterone is within normal male limits or your hormone balance is more testosterone less estrogen, both anti androgens and estrogen will be important in your hormone replacement therapy. testosterone is more potent than estrogen, so it's important to have low quantity of it for estrogen to work effectively.

[Rosa]

My testosterone levels were almost non-detectable before I was put on Testosterone replacement therapy.  I've not taken it for years now, and am planning to get the levels rechecked.  I'm wondering if I should check my Estrogen levels too, or does that not matter in regards to HRT?

[xxUltraModLadyxx]

My testosterone levels were almost non-detectable before I was put on Testosterone replacement therapy.  I've not taken it for years now, and am planning to get the levels rechecked.  I'm wondering if I should check my Estrogen levels too, or does that not matter in regards to HRT?

before starting hormones, my doctor wanted me to get a blood test. they will look at your hormones, so they know what you're working with already. you'll have to leave that answer to a doctor who would prescribe them to you. they would look at your estrogen since that will determine what dosage is best for you.

[Annah]

no: you still have to take Anti-Androgens according to your t-levels. Klinefelter people still produce t.

[marcy319]

T and E are not "opposites" any more than your car key is the "opposite" of your house key. They just do different things. Even natal females create a certain amount of T from the adrenal glands. If your T is less than 100 then you probably don't need AA... why take another pill if you don't have to? But that's up to your doctor of course.

[supremecatoverlord]

Yeah, even bio-females without chromosomal disorders produce small amounts of testosterone, so... ><
You probably could get away without it since Kleinfelter's promotes androgyny anyway, but it's probably safer to talk to a doctor about that.

[Rosa]

I went and got blood tests for T and Estradiol in hopes of being able to start E soon if I can just afford the doctor fees (got a good deal on the blood tests).

[Assoluta]

I don't know whether I have some kind of intersex condition as I never had facial hair, always had hips and had a small frame but as far as I know I started as a physically normal genetic male with average testosterone levels. I never took anti androgens for four and a half years and the estrogen worked just fine and in itself it reduced the T levels. In fact my T levels reduced to the normal female range with estrogen alone and in fact my estrogen level became too high and I had to reduce my dose, although I needed Anti Androgens just before the surgery as T levels somehow rose after being in the female range for several years.

So I'd say that anti androgens aren't necessarily a pre-requisite for HRT but I'm sure your endocrinologist or doctor would know what is most suitable for you.

[xxUltraModLadyxx]

I don't know whether I have some kind of intersex condition as I never had facial hair, always had hips and had a small frame but as far as I know I started as a physically normal genetic male with average testosterone levels. I never took anti androgens for four and a half years and the estrogen worked just fine and in itself it reduced the T levels. In fact my T levels reduced to the normal female range with estrogen alone and in fact my estrogen level became too high and I had to reduce my dose, although I needed Anti Androgens just before the surgery as T levels somehow rose after being in the female range for several years.

So I'd say that anti androgens aren't necessarily a pre-requisite for HRT but I'm sure your endocrinologist or doctor would know what is most suitable for you.

it's hard to say. you could've had androgen insensitivity from what you describe, but once you get on hrt/live fulltime, it basically ceases to matter.

[Assoluta]

it's hard to say. you could've had androgen insensitivity from what you describe, but once you get on hrt/live fulltime, it basically ceases to matter.

Yes, at a guess, it is possible I had androgen insensitivity, although it'd only be very partial as I had no genital abnormality such as a hypospadia. The only abnormality I had physically was an unretractable foreskin, and 'not much material to work with for GRS' to quote Mr. Bellringer, but such problems can be common with many genetic males.

[Rosa]

I think I'm always going to hold some bitterness towards the doctor that put my on T when I was in my early 20's.  Transition would be much easier if I had not taken T, but I didn't have anyone to talk to in confidence at the time, there was no Internet, and I thought taking T would make me "normal" - ha.  So now I have to deal with what most MtF have to deal with in regards to voice and facial hair, though perhaps not to the extent as some, since I was not very faithful at taking my T.