My parents were amazingly accepting when I came out, swapping all their pronoun / name usage within a month, and generally being more encouraging than anyone could ask for. But I can see that my mum is definitely still struggling, despite her best efforts, to come to terms with me taking hormones and all the changes they'll bring (particularly boobs and sterility, being that both are eventually permanent). I think it's one thing to accept it when all that has changed are words and frivolous things like clothes, makeup and accessories, but when real physical changes begin, the full extent of what is happening suddenly becomes apparent, and that can be scary, even for parents who want to understand. So no, ultimately I don't think they're ever ready for it. For their child coming out, perhaps, but not for the full extent of the changes. It's simply something that very few people have experience with. And I think it's something that parents have to feel out as they go, getting used to and becoming okay with each new step as it comes along.