Nine months on E and I've been pretty fortunate in terms of side effects; no weight gain, no noticeable mood changes, stable numbers on all my lab work. There's only been one exception to this rule: When, and only when my dosage is interrupted in some way, I do have some mood problems. When I was on the patch, I'd have problems whenever it came off early, and after switching to the pill, if I miss even one it completely ruins my day. I'm normally a pretty level person (at least since my transition started) but it's gotten really bad; not that I'm ever exactly bubbly, but I don't know if I should stop taking these things or what. I've been told by my GP that there's no way this could be the cause, but I can't seem to find another explanation. Anyone else had this experience? Thanks!