Nine months on E and I've been pretty fortunate in terms of side effects; no weight gain, no noticeable mood changes, stable numbers on all my lab work.  There's only been one exception to this rule: When, and only when my dosage is interrupted in some way, I do have some mood problems.  When I was on the patch, I'd have problems whenever it came off early, and after switching to the pill, if I miss even one it completely ruins my day.  I'm normally a pretty level person (at least since my transition started) but it's gotten really bad; not that I'm ever exactly bubbly, but I don't know if I should stop taking these things or what.  I've been told by my GP that there's no way this could be the cause, but I can't seem to find another explanation.  Anyone else had this experience?  Thanks!

I've "missed" pills more than a couple times and not much happened because my levels wend to be low for whatever reason so I'm guessing it's half that and half psychosomatic (expecting a certain feeling hormonally generated).

I suggest it is psychosomatic. I started to develop menstrual moods and then had my hormone levels checked daily, because I can. No change at all on daily levels, I'm on implants and I even have the day hour to hour changes that should be there, called diurnal changes, our hormones and lots of things change in a 24 hour cycles.

Just relax, the adrenaline boost from worry may be causing the affect. Adrenaline is powerful!