I don't have experience with clubs and binders, but I do have tons of experience with clubs and different outfits.
I think as long as you stay hydrated and don't wear a ton of layers over your binder (just one shirt is ideal), you should be fine. That's without partaking in any illegal substances. If you're planning on any sort of plant or powder or pill, I would say go binder-less and rock the androgynous look. Fatalities from club drugs are caused primarily by overheating.
It also depends on what sort of dress code. Is this a tee shirt and shorts kind of place or a dress shirt and slacks kind of place? The former is much more binder-friendly. Is this a casual, socializing type of event where you want to stay looking nice or an event where everyone will be dancing and getting sweaty?
Clubs usually have an outdoor smoking area you can escape to for cooling off if you need. I think it depends on how you are most comfortable.