Spiro question

[Amy1988]

Does testosterone get converted to estrogen while on spiro?

[Flan]

Does testosterone get converted to estrogen while on spiro?

no

[Amy1988]

no

Seems I read somewhere that T just floats around in the body since it can't bind to receptors and gets converted to E. 

[KayXo]

Does testosterone get converted to estrogen while on spiro?

It appears that some does get converted to estrogen.

Drug-induced gynecomastia: an evidence-based review
September 2012, Vol. 11, No. 5 , Pages 779-795

"Spironolactone acts as an anti-androgen by binding to the androgen receptors; lowers circulating testosterone by increasing its metabolic clearance and preventing a compensatory rise in testicular androgen synthesis; displaces estrogen from sex hormone-binding globulin (SHBG) and increases the peripheral conversion of testosterone to estrogen leading to elevated estradiol [12]. Estradiol levels decrease and testosterone increase significantly 3 – 6 months after stopping spironolactone [12]."

J Urol (Paris). 1981;87(9):635-8.
[The influence of spironolactone on the concentration of gonadotrophins and gonadal hormones in prostatic hypertrophy (author's transl)].

"The authors examined the influence of spironolactone on the concentration of testosterone, 5 alpha - dihydrotestosterone (DHT), progesterone, oestradiol (E2), LH, and FSH in 47 patients with prostatic hypertrophy, aged from 60 to 80 years. The control group consisted of 58 men of the same age."

"There was a considerable fall in the concentration of testosterone and of DHT and, at the same time, an increase in the concentration of progesterone, E2 and LH. After treatment with spironolactone there was a decrease in the size of the prostate gland. Results obtained show that spironolactone is an effective drug in the treatment of prostatic hypertrophy, since it inhibits androgen metabolism."

[Amy1988]

It appears that some does get converted to estrogen.

Drug-induced gynecomastia: an evidence-based review
September 2012, Vol. 11, No. 5 , Pages 779-795

"Spironolactone acts as an anti-androgen by binding to the androgen receptors; lowers circulating testosterone by increasing its metabolic clearance and preventing a compensatory rise in testicular androgen synthesis; displaces estrogen from sex hormone-binding globulin (SHBG) and increases the peripheral conversion of testosterone to estrogen leading to elevated estradiol [12]. Estradiol levels decrease and testosterone increase significantly 3 – 6 months after stopping spironolactone [12]."

J Urol (Paris). 1981;87(9):635-8.
[The influence of spironolactone on the concentration of gonadotrophins and gonadal hormones in prostatic hypertrophy (author's transl)].

"The authors examined the influence of spironolactone on the concentration of testosterone, 5 alpha - dihydrotestosterone (DHT), progesterone, oestradiol (E2), LH, and FSH in 47 patients with prostatic hypertrophy, aged from 60 to 80 years. The control group consisted of 58 men of the same age."

"There was a considerable fall in the concentration of testosterone and of DHT and, at the same time, an increase in the concentration of progesterone, E2 and LH. After treatment with spironolactone there was a decrease in the size of the prostate gland. Results obtained show that spironolactone is an effective drug in the treatment of prostatic hypertrophy, since it inhibits androgen metabolism."

I knew I had read that somewhere.  Thanks for posting it.