I know this doesn't sound very original, but what about a show about two or three trans people (including both M2F and F2M) and friends going about life? Sort of a soap opera where some people being trans is just part of the life. Trans issues would come up naturally, along with non-trans issues. The big win would be showing that trans people are just people, and while they're different from cis people, they aren't any more different than cis people are different from cis people.
However, I think the most important thing is to have trans people involved in it at a high level and with authority to get things changed as necessary. If the writing, directing, and production are left to cis people, the trans people are going to get othered. We've seen this again and again with marginalized groups. Like "Stonewall", which gave a white- and cis-washed version of the Stonewall riots intended to not make straight audiences uncomfortable.