Well I would presume if they did not say much about the times they feel it does not matter much.
Here is a graph showing that it really matters:
https://www.susans.org/forums/index.php/topic,186946.msg1665088.html#msg1665088With sublingual intake levels rise fast, and drop after a few hours...
Sublingual intake bypasses the liver and thus causes less clotting factors and less strain on the liver.
So spreading the daily dose in a few small doses might be a good idea.
Otherwise there might be a menopausal like effect a few times a day which might affect mood.
The same is true for swallowing pills if times of intake are far away from each other, like once a day.
For sublingual intake micronized bioidentical estrogen like estrace or generics are ideal.
You might talk all of this through with your doc.
*hugs*