So I'm wondering if there is any benefit in spreading out dosages, or any real loss at taking it all at once.  Im supposed to take three tablets daily but that's as much as I know.  Originally when I only took two a day I just took them at once, but since I upped everything I've been trying to take them every four hours or so.

But honestly it would be much more convenient to just take it at once and be done with it

You really should be asking your prescribing doctor this. And really, they should have told you in the first place.

Well it's good I'm going to see them in a short while.

I got directions for the Spiro but not much for the e

Well I would presume if they did not say much about the times they feel it does not matter much.

Here is a graph showing that it really matters:
https://www.susans.org/forums/index.php/topic,186946.msg1665088.html#msg1665088

With sublingual intake levels rise fast, and drop after a few hours...
Sublingual intake bypasses the liver and thus causes less clotting factors and less strain on the liver.
So spreading the daily dose in a few small doses might be a good idea.
Otherwise there might be a menopausal like effect a few times a day which might affect mood.
The same is true for swallowing pills if times of intake are far away from each other, like once a day.

For sublingual intake micronized bioidentical estrogen like estrace or generics are  ideal.

You might talk all of this through with your doc.


*hugs*