Even in the basics of fundamental genetics, gender variance is prevalent from the teachings.
I mean it has never just been male/female in the teachings that I went through. Yes there is the basics of XX and XY, in the sex chromosomal layout. There is also Turner syndrome X_ which lacks the second sex chromosome and also a variable Klinefelter syndrome XXX, XXY etc...
What a lot of older models of principles in the basics of genetics, is just outdated not to include this. In my brief study in basic genetics, it is not just the XY chromosome in which decides upon the male physiology, granted most of the time it does give the outward appearance. But from study I have gained knowledge that part of the reason of the general male output is a specific gene "SR Y" which usually is on the Y sex chromosome.
There does seem to be involved of either an irregular occurrence in which displaces this gene, and it wont exist, therefore in a conclusive "XY" female, or even in a replacement on an XX with the "SR Y" gene either attached on the sex chromosome or one of the autosomal chromosomes, which would be given an "XX" male.
So not to include all these different outcomes of genetic structures as well as more recent study in which gives more light in our own biological background, would be to not convey the right message within biology. These truths of more modern biology figuring out the human genome is a mere evolution within the biological system. Which means those who do not understand or know this about biology is just behind the times.
Kate <3