Thanks for asking a question I took have been curious about as I've been in a calorie deficit nearly my entire time on HRT and had the same questions/worries as you if I was hurting/delaying physical changes because of it! Nearly same situation like you 10.5 months HRT, just under 5'9 was 243 when I started now I'm about 165ish, used to be a Mens XL/border XXL in shirts and 44 in pants now I wear Womans size M shirts with some room in them too and size 12 pants, just the mental aspects of wanting to live/motivation to lose weight/get healthy since starting HRT have been the best thing ever, never knew I'd ever smile even that time ago >_< Have just about 10 more pounds at the most to lose, I have a slightly large frame, not huge but as much as I'm jealous wishing I could be 135 pounds with my frame I'd be sickly if not completely skeletal in appearance or dead. 155 is a perfect weight for me as I'd be squarely into the healthy weight BMI, be very skinny and just enough fat in places where I want to round out, even at 165 my ribs are getting quite pokey, and face showing a bit more bones but still roundish, curse my genes/bodytype to store most of my fat in my thighs/legs!