Quote from: Devlyn Marie on May 17, 2017, 03:03:19 PM"While estrogen pills can be dangerous for people with liver problems
There are different types of estrogen and it is imperative to specify which type we are speaking about. Why? Because bio-identical estradiol is metabolized much more efficiently and rapidly than are non bio-identical ones (because foreign to the body) so that the latter recirculate through the portal vein again and again, triggering changes in clotting factors that increase the risk of a formation of a blood clot in the veins. Studies have confirmed, time and time again, that the differences are significant. For instance, it's been estimated that ethinyl estradiol's impact on the liver is between 500 to 2,500 times stronger than estradiol.
There are studies in ciswomen with advanced breast cancer and studies in transwomen where moderate to very high doses of oral bio-identical estrogen were used and none of them ever showed liver complications while the risk of DVT remained quite low despite the advanced age of the patients (up to 92 yrs old).
Please pay attention to what type of estrogen they are referring to. This is of paramount importance.
QuoteA 2007 study also showed that the patch does not pose a risk of blood clots in postmenopausal women like oral estrogen does
Was the oral estrogen conjugated equine estrogen (Premarin) or bio-identical estradiol? If it was bio-identical, did the administration of this type of estrogen lead to an actual occurrence of DVT or pulmonary embolism?
QuoteRight now, all estrogens carry the same black-box warning with respect to clot formation."
Because pharmaceutical companies prefer to be overcautious to protect themselves. Studies, on the other hand, clearly show the risks to be greater with non bio-identical forms of estrogens taken orally.
As regards to one form of administration being superior to another, it's neither substantiated nor confirmed in transwomen. What matters is the individual's particular sensitivity to hormones and the dose prescribed. Some do VERY well on patches and oral, some do poorly on injections. Just to illustrate, I had much greater breast growth on oral than on injections, despite the fact that my levels were significantly higher on oral. It DEPENDS. I'm actually thinking of going back to oral.
