Quote from: Devlyn Marie on May 17, 2017, 03:03:19 PM"While estrogen pills can be dangerous for people with liver problems

There are different types of estrogen and it is imperative to specify which type we are speaking about. Why? Because bio-identical estradiol is metabolized much more efficiently and rapidly than are non bio-identical ones (because foreign to the body) so that the latter recirculate through the portal vein again and again, triggering changes in clotting factors that increase the risk of a formation of a blood clot in the veins. Studies have confirmed, time and time again, that the differences are significant. For instance, it's been estimated that ethinyl estradiol's impact on the liver is between 500 to 2,500 times stronger than estradiol.

There are studies in ciswomen with advanced breast cancer and studies in transwomen where moderate to very high doses of oral bio-identical estrogen were used and none of them ever showed liver complications while the risk of DVT remained quite low despite the advanced age of the patients (up to 92 yrs old).

Please pay attention to what type of estrogen they are referring to. This is of paramount importance.

QuoteA 2007 study also showed that the patch does not pose a risk of blood clots in postmenopausal women like oral estrogen does

Was the oral estrogen conjugated equine estrogen (Premarin) or bio-identical estradiol? If it was bio-identical, did the administration of this type of estrogen lead to an actual occurrence of DVT or pulmonary embolism?

QuoteRight now, all estrogens carry the same black-box warning with respect to clot formation."

Because pharmaceutical companies prefer to be overcautious to protect themselves. Studies, on the other hand, clearly show the risks to be greater with non bio-identical forms of estrogens taken orally.


As regards to one form of administration being superior to another, it's neither substantiated nor confirmed in transwomen. What matters is the individual's particular sensitivity to hormones and the dose prescribed. Some do VERY well on patches and oral, some do poorly on injections. Just to illustrate, I had much greater breast growth on oral than on injections, despite the fact that my levels were significantly higher on oral. It DEPENDS. I'm actually thinking of going back to oral.

Quote from: KayXo on May 18, 2017, 11:00:03 AM
As regards to one form of administration being superior to another, it's neither substantiated nor confirmed in transwomen. What matters is the individual's particular sensitivity to hormones and the dose prescribed. Some do VERY well on patches and oral, some do poorly on injections. Just to illustrate, I had much greater breast growth on oral than on injections, despite the fact that my levels were significantly higher on oral. It DEPENDS. I'm actually thinking of going back to oral.

Welp, that was not much help!  LOL 
Just kidding.

I think the key is that here is no clinical research out there for HRT for feminization but, rather, it is all for HRT for menopausal women.
Which is not directly applicable to trans women because trans women want to feminize, not maintain a sustaining level to fend off hot flashes..

Quote from: Sarah.VanDistel on May 11, 2017, 02:16:36 AM
Hi GrayKat! Doing shots myself now too, since a couple of weeks, every 10 days (I won't specify the dose, though). I found the IM injection (ventrogluteal site) surprisingly painless! What about you? And as for other symptoms, nothing so far. Girl's dope seems to be smoothly doing its thing... So much more practical than pills. I used to take the pills twice a day, so sometimes it wasn't that practical, even though I always carried a couple of doses in my pocket, inside their blister. I still have to remember to take the AA (I take it 3 times a day) and for that I keep different alarms on my smartphone. Hope my hormone levels will be good! I trust they will... 😌 I hope your experience will be as positive as mine!
Hugs, Sarah

edited: couple of minor typos.

Sent from my SM-T810 using Tapatalk

Actually, I find them quit painful. Not the shot itself, I end up with a big painful lump that lasts for two weeks

Quote from: GrayKat on May 21, 2017, 10:57:51 PM

Actually, I find them quit painful. Not the shot itself, I end up with a big painful lump that lasts for two weeks

Hummm... That's odd. I don't know how much volume you get (me 2 mL) but it's definitely not normal to get a lump, unless there's some sort of local reaction, the volume of medication is too large (> 5mL) or the injection technique is inappropriate (not deep enough? local hematoma?). Was it the first time that you got the injection? Which site of injection are you getting injected on (ventrogluteal is the most appropriate and safest for large volumes, i.e. 2.5-5mL)?
Yours truly, Sarah

Sent from my GT-I9505 using Tapatalk

Quote from: GrayKat on May 21, 2017, 10:57:51 PM

Actually, I find them quit painful. Not the shot itself, I end up with a big painful lump that lasts for two weeks

  Hi,

  That doesn't sound right at all. Perhaps you hit the wrong place or possibly not injecting yourself correctly. Have you consulted your doctor about this?
  Hope you get it resolved soon.

Hugs,
   Laurie

I take XXml, the 'beginner' amount.  At this dose, I feel nothing.  I sent her an email but have not heard back yet.

Sorry for interjecting: posting of dosage information is not allowed on this site. If you can please edit your posts and remove the dosage information. Thanks!

Quote from: GrayKat on May 22, 2017, 07:24:56 PM
I take , the 'beginner' amount.  At this dose, I feel nothing.  I sent her an email but have not heard back yet.

Quote from: sarah1972 on May 22, 2017, 08:42:37 PM
Sorry for interjecting: posting of dosage information is not allowed on this site. If you can please edit your posts and remove the dosage information. Thanks!

OK, done 

Well, I tried a new vile and I am not having the same side effects. With the first vile, when I injected it into my leg it felt like hot coals going into my leg. The burning persisted for days. I tried to downplay it because I wanted it so bad. The reaction was horrible.

  It could have been a bad batch in the vial or perhaps it was expired? At any rate did you see if you could return the vial for a refund or exchange? The vial should have a date on it.

Hugs,
   Laurie

I am going to contact my doctor and see if I can get a replacement.