I have been on a combined Oestrogen and Progesterone regime (promethium) for just a little over one year. I take Oestrogen tablets twice a day on days 1-16, then adding an evening Progesterone tablet (at night time) from Days 16-30.
I dont take any blockers.
After about 7 months on the combined regime, I noticed an enlargement of my aureolas during my monthly cycle and a girlfriend mentioned that they looked just like hers during her pregnancy. It's not a permanent thing, but my areolae and nipples are definitely more noticeable at the second part of my monthly cycle.
Judith Lynn