All the time and for the reasons you mentioned.
IMHO if she is not supportive now, expect your marriage to end and be prepared for that. My ex and I loved each other immensely, and still do, but a number of factors led to our split including not the least of which was her family. Be prepared for that possibility - she signed up to be with a man.
I was exactly your age when I started transitioning, and it's a tough thing to do but for many of us necessary. I do think that a large degree of actual violence is from the trans person placing themselves in an environment with a higher risk. Not all obviously, but as with any woman, being aware of your environment and taking precautions is the best thing you can do. Also remember not all violence against a trans person is a hate crime, some of it is the normal situational bad luck and some is domestic. Be smart, be aware and trust instincts. Personally as my transition has progressed, so too has my safety and comfort levels, but then you also get used to having a different social role.
Be prepared for every relationship you have to change. Some are lost, some get stronger and others just change and it's all unpredictable.
Your career will be fine if you manage it appropriately, while bigots do exist for sure - employers care about making money or achieving a goal. If you are the best person to do that then you get hired. It is expensive to recruit new talent so unless you mishandle your career, behavior, attitude or performance, I believe you'll be fine. I do not buy into the "I'm trans so I'm unemployable" BS, and have personally received the largest raise in my career while I was transitioning. Just do your job and keep knocking it out of the park.
Is it worth it? For me absolutely 100% yes but only you can decide that. I've known about my "trans ness" my whole life and reached a point where every coping mechanism I had failed and no amount of therapy was going to fix that. So for me it was a choice to live. Not everyone gets to that point and not everyone needs to transition to put the dysphoria at rest.