Based upon my opwn experience and my own story, I would say yes you can, BUT it depends on what you want to get out of it. Why do you think you are transgender? Or are you sure you are Transgender? For me, I wasn't entirely sure, so I needed to take some small measured steps to explore this side of myself.
For me, it wasn't so much about hating my male body, but something deeper, at my core and my emotional center was just off. So I wanted to see how changing this one small thing made me feel. So when I started, those questions and doubts went away after a short time on Estrogen, and I could just be.