I don't think Republican talking points really need to be taken too seriously, because they are largely BS used to rally the base and discourage the opposition. Just ignore the bullies for a moment.
The Democratic candidates will be fine if they spend more time affirming their own merits through their ideas and goals and less time nitpicking trivial details (that's a big turnoff and is frankly wasted energy that brings down the debate to a level conservatives thrive against) and comparing their opponent unfavorably to McCain (I'm looking at you, Hillary). Connecting with moderates in the main election requires that they emphasize how their goals in office relate to voters... and when they deal with complicated issues like gender identity (something we around here tend to find important), it's going to take a lot of explaining, educating, and clarifying (which has to cut through the rhetoric of the opposition party), and that doesn't leave them with much spare time to cut down opponents within their party.