First yes, then no.
From childhood I grew up very socially isolated. I had few or no friends. After all, the world of boys made no sense to me and I found it repellent. I felt affinity with the girls and longed to participate in female society, but it was barred to me. That left solitude, pretty much. I came to feel comfortable in solitude and was socially awkward. During most of those years I had no friends at all, unless I got a chance to be friends with women, which was often problematic. This held true until I came out when I was 45.
At that time the social butterfly emerged from her chrysalis and all of a sudden I had an active social life and more friends at one time than I'd had in the rest of my previous life put together. I came out of my shell and reached out to other humans, and discovered how much I enjoyed human contact and how easy it was. The reasons for this dramatic transformation are easy to see: I found activities where I felt welcomed and fit in-- first the peace movement, then Paganism, and then the LGBT movement. Embracing Pagan faith not only proved liberating for my gender issues, it brought me into contact with many wonderful people who instantly became good friends. The same went for LGBT activism. The two went together because Paganism tends to be the most queer-friendly religion, while many queer people with a spiritual bent find Paganism beneficial to their lives.
But the main reason I suddenly became a social success was that I now accepted who I am-- for only by living on the basis of my true reality could I relate well to others. This allowed my inherent friendliness and charm to shine openly instead of being blocked as it was during those long grim years of gender inhibition.
I've always been introverted, and still am. But introversion does not mean you can't be outgoing and have a social life. I'm an introverted social butterfly who can't get enough of going to parties, throwing myself into activities, and making new friends. What introversion means is that I still need my solitude (several hours a day) to recharge my energy. But now I've found more of a balance, so that I can enjoy both social life and solitude. Coming out was the healthiest thing I've ever done, that is for sure.