Quote from: Melan on January 20, 2009, 11:15:29 AMIs there a study that proves that progesterone adds to breast development? I've heard and read that it adds to breast development in many places ...
Size enlargement is usually temporary due to engorgement, but some people have had further increases after adding P. The more permanent effect though is that it allows the breast to develop a fuller, more natural shape because ductile tissue develops, as far as I understand it anyway.
[/quote] ... but cannot get my Doc to prescribe Prometrium to me. He says its potential for harm (increased risk of heart attacks and blood clots) is too great, and that MtF transpersons have no receptors for progesterone. He seems pretty sure in his conviction on this, and surprised that I came to him wanting it added to my script list (both times I tried, *giggles*).[/quote]
Again, I'm not an expert, but what he is saying about receptors seems totally incorrect. The P receptor is encoded on chromosome 11
(ref), which is identical in males and females. Even if he were arguing that the receptors are somehow disabled in males, he would still be incorrect, as these studies that specifically target P-receptors in males and their role in male sexual function show:
Progesterone receptors mediate male aggression towards infantsProgesterone receptors, various forms and functions in reproductive tissuesRegulation of male sexual behaviour by progesterone receptorAs to health risks, the problem is that he's equating bio-identical progesterone with progestins, which are synthetic analogues of progesterone. The negative side-effects you refer to are all associated with progestins, not progesterone. Unfortunately though I have the same problem with my doctor, though I've only asked him once. I'm hoping I can convince him this time around, though I'm thinking probably not 'cause he'll have "cancer lawsuit" at the back of his mind, and what do I know, I'm not an endocrinologist (pretty-much his attitude last time around)
If you wanna try and convince him anyway though, I've sent you a PM with a really good summary of a whole slew of progesterone studies out there. Unfortunately it has dosage info in there, so I can't post it publicly. Sorry all.
Mina.