This was something I was always paranoid about when I started HRT about 3 months ago, so I didn't drink at all. But my blood work is fine and I seem pretty healthy so I don't think having a few drinks every once in a while will cause a major problem. I don't drink liquor anymore either, I stick to beer or wine. Keeping it to a weekend thing and not drinking alot often you should be ok... but everyone is different. As long as you get blood work taken often and know you are healthy I don't think having a few drinks every once in a while will hurt you.