QuoteI know lots of people that had much better results taking cyproterone acetate but it is not FDA approved, so if you are in the US you would have to import it. It is widely used around the world and I am not sure why it isnt FDA approved.
A lot of writers in the chinese TG forum similarly recommended Androcur over Spiro (even warned about Spiro's negative effect), but I'm more in favour of Spiro due to lesser adverse effects after reviewing the facts on paper.
I quote below the adverse effects of cyproterone acetate (Androcur), hopefully it answered why it isnt FDA approved:
Cardiovascular system
hypotension, tachycardia, heart failure, syncope, myocardial infarct, hemorrhage, cerebrovascular
accident, cardiovascular disorder, retinal vascular disorder, embolus, pulmonary embolism,
superficial and deep thrombophlebitis, thrombosis, retinal vein thrombosis, phlebitis, vascular
headache, shock.
Gastrointestinal system
constipation, diarrhea, indigestion, anorexia, nausea, vomiting, cholestatic jaundice, cirrhosis of
liver, hepatic coma, hepatitis, hepatoma, hepatomegaly, jaundice, liver carcinoma, liver failure,
abnormal liver function test, liver necrosis, pancreatitis, glossitis.
Hematology
increased fibrinogen, decreased prothrombin, thrombocytopenia, anemia, hemolytic anemia,
hypochromic anemia, normocytic anemia, leukopenia, leukocytosis.
Metabolism
negative nitrogen balance, decreased response to ACTH, hyperglycemia, lowered cortisol,
hypercalcemia, increased SGOT, increased SGPT, increased creatinine, hypernatremia, edema,
weight gain, weight loss, diabetes mellitus.
Musculoskeletal system
myasthenia, osteoporosis.
Nervous system
fatigue, lassitude, weakness, hot flashes, increased sweating, aphasia, coma, depression, dizziness,
encephalopathy, hemiplegia, personality disorder, psychotic depression, abnormal gait, headache.
Respiratory system
asthma, increased cough, dyspnea, hyperventilation, respiratory disorder, shortness of breath on
effort, lung fibrosis.
Skin
eczema, urticaria, erythema nodosum, exfoliative dermatitis, rash, maculopapular rash, dryness of
the skin, pruritus, alopecia, hirsutism, skin discolouration, photosensitivity reactions, scleroderma.
Sensory system
ear disorder, optic atrophy, optic neuritis, abnormality of accommodation, abnormal vision,
blindness, retinal disorder.
QuoteMy first three months on HRT was spent taking a fairly high dose of spiro and a medium dose of E, but my T levels were still 650. So the doc took me off the spiro and put me on depo shots every three months, as well as doubling my dose of E.
First, be aware that spiro itself does not decrease T level, it merely replaces T receptors, blocked its effects, in the process aim to lead to atrophy of testis within the period of at least six month, after which production of T will be low to non-existence.
Considered the fact that you are only on three month HRT, the level of T is not indication that the process of testis' atrophy had not already taken place, since the level of T at this time has no effect on the body due to Spiro taken their places. Thus withdrawer of Spiro at this point of test result is illogical to using spiro as a route of therapy.
As someone pointed out, your BMI does affect how much effect estrogen has on fat distribution (the main physical change).
