My apologies. I'm new here. Is that a spoiler tag you made? If so how can I make it? If not I'll reduce the info to just the games

I've had games bring a lump to my throat but right now I can't think of one that made me cry.
Farenheit & Heavy Rain came close.
I am close to tears however after browsing the list & not seeing Shadow of the Collosuss, Some of those giant beasties deserved to die because they tried their best to kill me.
Two stand out for making me feel very guilty for killing them, the first one in the game ignored me until I stabbed him in the leg, I then climbed up him & stabbed the poor creature repeatedly in the head.
The flying one in the desert also made me feel bad about myself as it was content to just fly around until I deflated its airbags with my bow & arrow, I then pounced on it when it was struggling to stay airborne & set to work slaying it.

Not just a great game but the best single player game ever

Yes I cried at Aeris death in FFVII.

Mass Effect 3 made me cry during the final run with the Love Interest. But it had a few more tearful moments. I was truly sad about Mordin on Tunchunka. I would even venture further back to ME2 with their Shadow Broker expansion, it was a sad moment but more of a happy cry moment. Really if you played the game from the beginning its actually a worth while story, up to the end just make sure you get the extended content stuff for ME3. Or else the ending is going to be junk.

Zone of the Enders (PS2)
Final Fantasy 7 & 8

Kingdom Hearts, Final Fantasy 8, Lost Odyssey, Heavy Rain, Journey.

When E 102 died in Sonic Adventure ;__; he killed himself to free the animal that was inside of him so it could be with its family... So touching.

I think I RPG'd myself out in the 16-bit era, when every friendly character death was an almost farcical hyperdrama.  You just stop caring after a while (WAY TO DIE AT LVL 70 ON A NEW GAME+, CRONO).  By the time I started hitting RPG's with stories I could take seriously, I think I was just inoculated against feeling sad from playing a video game.

Seriously, just get through the entirety of Tales of Phantasia, and you'll never take any sad scene in a video game seriously again.  I mean it.

Which is actually weird because I'm probably too sensitive to this kind of stuff, and I cry a lot.  Actually, now that I think about it, I just have a totally different relationship with video games than with other media.  Sad scenes in video games are fine, but I can't watch sad movies without crying and feeling upset for hours.  And I try pretty hard to avoid TV shows where things don't magically "work out" in the end because they leave me feeling bad.  Same thing with violence.  I leave the room and go do something else when my boyfriend watches an episode of Boardwalk Empire because that show is too much for me.  But I can blow people up like nobody's business in video games!

War of the Worlds on Xbox arcade, when you've died a thousand deaths due to poor controls & collision detection then you'll shed a tear or two. When you've heard Patrick Stewart repeat the same line over & over every time you respawn you forget what a lovely voice he has & start wanting to rip  his voice box from his body!

It's such a shame because the game starts brilliantly with the voice over being done by the almighty Captain Picard but then you take control & things rapidly go downhill, it's a waste of time, money & a a great way to blemish the fine legacy of the War of the Worlds.
H.G. Wells must be turning in his grave at this travesty

Never had a game make me cry, but Red Dead Redemption was about the saddest game I can remember.

Spoiler!!!

John Marston fights through the entire game just to get out from under the FBI and settle down with his family.

He gets home, you do a few sedate farming missions, and then they come and gun him down for no real reason.

Okami and Okamiden.

Kingdom hearts Daysa and BBS.

Dynasty Warriors 7.

So far anyway.

well one of the games that make me cry everything is not by sadness but scare
when i play minecraft with friends i usualy do skype calls with a friend or two and we play toghter
tthen there are those green creeper things that always creep behind us making our hearts fall down into our bottom

(Posted in order of play as well)

Final Fantasy 7 (3rd fav)
Final Fantasy 8 (tho not a fav of mine)
Final Fantasy 10 (2nd fav)
Final Fantasy 10-2 (eh 4th - for story line connection to 10)
Final Fantasy 7 - Dirge of Cerberus (my fav game of all time)

All i can think of right now.im an rpg type person,tho dragon age made me cry (for ps3) awesome game but its alittle diffrent then the ones i listed.

Spoilers:

The good ending of Far Cry 3 almost made me cry when Citra was accidently killed. However, once I looked at the bad ending though where Citra freaking kills me after having sex with her, I was glad that I didn't cry.

Halo Reach
*spoiler*
When Jorge decides to sacrifice himself for his homeplanet.
and the ending where the player has to stay behind to ensure the Pillar of Autumn escapes.

Okami and Persona 3 have managed to make my shed tears.
I think Asura's Wrath could do that, too if I'm in a certain state of mind while playing episode 12. It's just... so fricking sad.

As has surely been stated already, The Walking Dead.

Everything's gonna be OK, Clementine. I promise...

Homeworld was affecting, but not quite to crying levels.