Yeas, it does matter what state and city you live, and what you do for living.
Most of the top fortune 500 companies have TG/TS friendly policies and offer health insurances that cover SRS.
The attitude of the populations in the major metropolitan areas, specially those in the west coast, north Atlantic, and mid western states is in general positive towards TG/TS.
In Texas, I would stay in San Antonio or Austin (preferably Austin), and even Dallas, the rest...well..its if at best