No, detransitioning stories don't make me uncomfortable, just a little sad for the person who needs to do that, since as others have pointed out, the reasons almost never seem to be "I'm detransitioning because I feel I made the wrong decision regarding my gender" but almost always go "I'm detransitioning because I cannot pass or because I'm getting harassed or finding society does not accept me." This doesn't make it invalid of course, but it does seem to say that the problem truly does lie with society than with the transitioner. After all, most of us have lived with our dysphoria for many decades.... I personally know what and who I am, I did so for decades, and that hasn't changed now that I've had SRS. If I copped a lot of bad experiences from society, I might question my decision to wear female clothes for instance, or wear my hair a certain way, etc, and I might go back into drag (male clothes, binder, etc, like I have to do a few months each year when I travel to dangerous countries, one of which I actually call my home) full time. BUT I would never regret the surgery or doubt that I am female inside, even if I have to cover it up. Dam, I hate it when I ramble around a point, but maybe it's clear enough: detransitioning issues seems less about a person's intrinsic dissatisfaction with their OWN decision to "become a female" physically, and more about not being able to be accepted BY OTHERS externally.
Detransitioning, for some, is a valid choice, one for which I have nothing but sympathy.