On Saturday I'll be starting Spiro and upping my Estradiol and I'll be splitting my doses (so five pills a day including the Provera). Anyone have any suggestions on the best times to take them? My current schedule has me waking up about 9am and eating breakfast, then (hopefully) going to the gym. I try to have a small snack around noon, lunch at 3, another small snack at 6, and dinner at 9. Then I go to sleep around 2-3am. So my current plan is to take Spiro at noon, E at 3, P at 6 (which is when I currently take that and E), Spiro again at 9, and E again at midnight. I'm worried because I hear a lot of stories about frequent urination with Spiro so I don't want to take it too late. Does this schedule seem viable? Am I spreading it out too much?