I have been on Spironolactone for a month and on Estrogen for a week. I am starting to get some breast development, and they itch like crazy. Any advice on how to deal with the itching?

Get used to itching!*giggle* Wait until a door brushes them! OUCHIE

You will also soon find the attraction of new breasts to bang into inanimate objects with a painful outcome!

Look for a padded bra!

The itching usually gives way to soreness ...so just wait 

Welcome to being a woman! 

I use self-hypnosis techniques to make the itching bearable.

I tell myself that the itch is gradually decreasing in intensity until it feels only like a pleasant tingle.

I imagine in my mind how that feels. If I do that steadily, I find it does get a bit less acute.

It's not a miracle cure, but it does help diminish the agony.